Because certain experimental variables may have unknown biological threshold levels, lack of standardization may lead to have highly discordant results in different studies examining the same issue. While certain experimental techniques have been widely accepted and adapted following their use in papers generated by influential labs, lack of standardization has undoubtedly promoted heterogeneity of results.
At the same time, fundamental interspecies differences do exist and must be carefully accounted for if the experimental findings are to have clinical relevance. The great similarities in multiple aspects of thyroid physiology between humans and small rodents have facilitated the rapid translation of experimental findings to the clinical realm. Tens of thousands of publications indexed on PubMed ( feature cells or small animals made hypothyroid or thyrotoxic. From the identification of the long-acting thyroid stimulator to the discovery of antithyroid drugs, basic research studies have provided the fundamentals upon which our clinical diagnostic and therapeutic tools are based. O ver the past 150 years, investigators utilizing animal and cell culture–based experimental models have achieved landmark discoveries that have shaped our understanding of thyroid physiology and disease. These recommendations are intended to promote standardization of study design, which should in turn increase the comparability and reproducibility of experimental findings.Ĭonclusions: It is expected that adherence to these recommendations by investigators in the field will facilitate progress towards a better understanding of the thyroid gland and thyroid hormone dependent processes.
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In this document, a panel of experts commissioned by the American Thyroid Association makes a series of recommendations related to the study of thyroid hormone economy and action.
Summary: Important clinical practices in use today for the treatment of patients with hypothyroidism, hyperthyroidism, or thyroid cancer are the result of laboratory discoveries made by scientists investigating the most basic aspects of thyroid structure and molecular biology. Background: An in-depth understanding of the fundamental principles that regulate thyroid hormone homeostasis is critical for the development of new diagnostic and treatment approaches for patients with thyroid disease.
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